Scrambler Therapy in Treating Pain and Peripheral Neuropathy in Patients Previously Treated with Chemotherapy
http://www.mayo.edu/research/clinical-trials/cls-20116107
Mayo Clinic Clinical trial patient Karen Safranek report:
http://sharing.mayoclinic.org/discussion/breaking-away-from-the-pain-with-the-help-of-the-scrambler/
The Mayo Clinic Cancer Center reported in its quarterly publication, Forefront–Translating Research into Clinical Advances, (page 5, beginning on bottom left and continuing to right column):
“In addition, the group continues to evaluate promising therapies to alleviate CIPN. This work, using randomized, placebo-controlled studies, has helped better define agents that do not appear to be helpful and newly discovered
agents that look more promising. While no markedly effective therapies have been identified for treatment of established CIPN, the group continues to explore new and promising agents.
This work has included the study of the value of using an electrocutaneous nerve stimulation device, called MC-5A Calmare®, also known as “scrambler therapy.” The MC5-A Calmare® device provides cutaneous electrostimulation by simulating nerve action potentials and directly stimulating peripheral nerves.
The MC5-A Calmare® device is not thought to act just by inhibiting pain transmission, but instead by substituting “pain” information with “non-pain” information. It is thought that it does this by mixing another signal into the pain signal transmission, which replaces the original pain information, thus the term, “scrambler therapy.”
Based on pilot data from another group of investigators, supporting that this therapy was useful in patients with chemotherapy neuropathy, Mayo is evaluating this treatment in patients with chemotherapy neuropathy and other pain states. Initial data from Mayo support that this treatment looks promising and deserves to be evaluated in a placebo-controlled, randomized study.”
Update 2014:
Mayo Clinic oncologist and professor Dr. Charles L. Loprinzi reports to Reuters News Service about his clinical findings using Calmare scrambler treatment http://news.yahoo.com/video/scrambling-away-pain-cancer-patients-160603523.html
-
NCT ID: NCT01347723
Sponsor: Mayo Clinic
Principal Investigator: Charles L. Loprinzi
Protocol IDs: MC10CC, NCI-2011-00339
Purpose
RATIONALE: Scrambler therapy may help relieve pain from peripheral neuropathy caused by chemotherapy.
PURPOSE: This phase II trial is studying how well MC5-A scrambler therapy works in reducing peripheral neuropathy caused by chemotherapy.
Study Type: | Interventional |
Study Design: | Endpoint Classification: Efficacy Study Intervention Model: Single Group Assignment Masking: Single Blind (Subject) Primary Purpose: Supportive Care |
Official Title: | Scrambler Therapy for the Treatment of Chemotherapy Induced Peripheral Neuropathy: An Evaluation of a Sham Procedure and Phase II Trial |
September 27, 2018 at 12:25 pm
Are there any trials open now going on anywhere in the US for CIPN and Scramble therapy?
September 27, 2018 at 3:27 pm
Josseline,
Great question.
Thirty to 40% of all chemotherapy patients experience chemo-induced peripheral neuropathy.
To our knowledge, the most recent CIPN trial using scrambler therapy occurred at the Mayo Clinic, performed by Dr. Loprinzi. We did not see recent activity on this trial over the past few years, but know he and his group experienced positive outcomes.
Please keep in mind scrambler therapy is a ‘provider-dependent treatment.’ In other words, the patient is dependent on the skill and expertise of the doctor using the technology.
Here are a few related links:
https://www.yahoo.com/news/video/scrambling-away-pain-cancer-patients-160603523.html
https://www.healio.com/hematology-oncology/breast-cancer/news/online/%7B39fb0977-4c06-4d72-8c04-841b6e172bba%7D/mayo-clinic-researchers-test-scrambler-therapy-for-pain
Feel free to call us directly if we can offer more information.
January 17, 2016 at 6:51 pm
I am begging for treatment
6 years of shingles 3o out breaks phn
24 hour pain.
Tried everything current
Many meds
Than I heard about Calmare scrambles
I live in fl a ormond beach.
Where can I go .I am so excited about living a normal life again
is it possible
Please help me
Rmcna830@aol.com
October 29, 2014 at 10:10 am
I do not see anything on the success rate of Calmare treatment for Post Herpetic Neuralgia. Where can I find this information?
October 29, 2014 at 4:34 pm
Thank you for your message Mr. Malkin. We have passed on your query to Dr. Michael Cooney. He will be in touch with you directly.
Pending her availability, we also have a PHN patient who underwent Calmare Therapy for her advanced Shingles condition and can talk with you directly via our Patient-to-Patient program. Thank you.
June 17, 2014 at 7:52 am
Hi Dr Cooney
Thanks for your response. I have wonderful news to share. I had an appt with Director of “Spine center” at Mayo regarding Clinical Calmare trails for RSD/CRPS.
They had decided to do them in three areas. Continue trail for chemo pts who develop neuropathic pain. Then one for chronic pain from Spinal conditions and lastly one for chronic pain assoc with RSD.
He selected me to participate in that trail. So happy about this. He said they have to train more staff in the use of the Scrambler machine and treatments are 30 minutes for 10 days. What and advancement this will be for all the RSD sufferers in the States surrounding MN.
I will keep you informed as to how it goes.
Sincerely, Glenda Andrist
June 14, 2014 at 11:44 am
I want to know if there are any Clinical trials being done using Calmare therapy for Chronic Pain associated with RSD/CRPS? I am very interested in being a trial candidate. Thankyou.
June 16, 2014 at 3:48 pm
Hi Glenda,
That’s a great question. To my knowledge, there are no MC-5A Calmare scrambler therapy studies in progress for RSD / CRPS patients (yet!).
As you know from our website, we have seen outstanding outcomes with the CRPS / RSD / RND patients we have treated since 2011. I’d be happy to share my insight with you. Feel free to call my office anytime.
Should any studies become available, I will be happy to let you know.
Best regards and thanks for reaching out, Dr. Michael J. Cooney Calmare Pain Therapy Treatment NJ
On Sat, Jun 14, 2014 at 11:44 AM, calmarenj wrote:
>