New clinical trial research finds Scrambler Therapy may provide meaningful relief for people living with treatment-resistant post-stroke nerve pain—without adding another medication or painful procedure.

By Dr. Jason Cooney, DC, Clinical Director | Scrambler Therapy Certified
For many stroke survivors, recovery doesn’t always end when they leave the hospital. Months—or even years—later, some people develop persistent nerve pain that can feel like burning, tingling, stabbing, aching, or electric shocks.
Known as post-stroke nerve pain or central post-stroke pain, this condition can interfere with sleep, mobility, rehabilitation, and overall quality of life.
Unfortunately, many patients discover that medications don’t always provide enough relief. Others stop treatment because of unwanted side effects.
If you’re battling chronic nerve pain after a stroke, it’s important to know that researchers continue to explore new, drug-free treatment options.
A recently published randomized, sham-controlled clinical trial from Johns Hopkins Bayview Medical Center evaluated Scrambler Therapy in patients living with chronic post-stroke nerve pain.
New Research Highlights the Potential of Scrambler Therapy
The clinical results were more than encouraging.
After just five consecutive Scrambler Therapy treatments:
🔷 Participants experienced an average 56% reduction in pain.
🔷 70% reported their pain had been reduced by more than half.
🔷 Four weeks later, many participants continued to experience sustained pain relief.
The study’s most important findings are summarized in the graphic below:

Learn More
🔷 Neurology Today Summary: Expert coverage of the Johns Hopkins clinical trial
Unlike muscle or joint pain, post-stroke nerve pain develops because the brain’s pain-processing pathways have been disrupted. As a result, normal sensations may be interpreted as painful long after the stroke has occurred.
Why Post-Stroke Nerve Pain Can Be So Difficult to Treat
Many post-stroke patients are routinely prescribed traditional pain management medications such as gabapentin, pregabalin, or certain antidepressants.
While these medications help some people, others continue searching for relief because their pain remains difficult to control or medication side effects become problematic.
This is the key reason researchers continue investigating non-drug therapies that may help manage chronic neuropathic pain.
How Scrambler Therapy Works
Scrambler Therapy is a noninvasive, drug-free treatment designed to help reduce chronic neuropathic pain by delivering gentle electrical stimulation through surface electrodes placed on healthy skin near the painful area.
Rather than simply masking pain, Scrambler Therapy is designed to help the nervous system process pain signals differently. Treatments are performed comfortably in the office without surgery or injections.
Conditions That May Respond to Scrambler Therapy
Although researchers are now studying its role in post-stroke nerve pain, Scrambler Therapy has also been used to treat a variety of chronic neuropathic pain conditions, including:
- Chemotherapy-Induced Peripheral Neuropathy (CIPN)
- Complex Regional Pain Syndrome (CRPS)
- Phantom Limb Pain
- Post-herpetic Neuralgia
- Chronic Post-Surgical Nerve Pain
- Other forms of treatment-resistant neuropathic pain
🔷 Learn more about the treatment-resistant, neuropathic pain conditions we treat:
https://www.calmaretherapynj.com/conditions-treated/
While this study is encouraging, it involved a relatively small number of patients, and larger clinical trials are already underway. Not every patient with post-stroke nerve pain will be an appropriate candidate for treatment.
Is Scrambler Therapy Right for You?
The first step is a comprehensive consultation to determine whether Scrambler Therapy may be appropriate for your specific condition.

🔷 Meet Dr. Jason Cooney, DC
If you’re living with post-stroke nerve pain and conventional treatments have not provided the relief you hoped for, you don’t have to stop searching for answers.
Schedule a Consultation
🔷 Click here to schedule a live phone consultation with Dr. Cooney within 48 hours of your message or call our New Jersey clinic at 201-933-4440 to speak with the doctor.